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My first response was that you should "put this in the back of your mind" if symptoms were not present. I have changed my mind. As you know PON 1 variants are associated with a higher risk for coronary artery disease. The current theories on this are that inflammation plays a key role. Toxins increase inflammation in the body and therefore a more proactive role is my current advice. I would do the hair test and have it interpreted over at the Cutler facebook page.

Andy Cutler Chelation group would be a great resource. If your mercury exposure was a long time ago, it would no longer be present in the blood, but in the tissues. Even hair tests that look normal can be misleading. The ACC group can look at your test and give you tips on how to read, and how to chelate safely.

The outstanding question is whether you have symptoms suggestive of heavy metal toxicity. There are no measurements that can account for brain-loading. But a hair test can disclose a "signature", if a person has the ability to read it.

Brain-loading s is particularly important with mercury which can become trapped on the other side of the blood-brain-barrier. As a concentration builds more symptoms develop. Meanwhile, "body loading" (minus brain loading, obviously) makes it look like a person is OK or borderline.

IOW....if you do not have symptoms that lead you down the heavy metal road then just keep the potential for this in the back of your mind. If you have symptoms, then get a hair test (the test needed is on this site) http://www.livingnetwork.co.za/chelationnetwork/chelation-the-andy-cutler-protocol/

Once the results are in, put them on the site and join FDC (Frequent Dose Chelation) on yahoo and have someone there look at them. My brother, Brian, would be a good choice. They will try to get you to choose the Cutler Protocol to chelate mercury from your system and it is your choice.

I was mercury toxic to the point of being "Mad-as-a-Hatter and used the Protocol to detox successfully.

What is mercury hypersensitivity? Well, officially, mercury hypersensitivity is a true allergic reaction to an amalgam filling, including redness, swelling, itching, and/or hives on the face/neck/torso. The term has come to mean something else in recent years--it refers to a person who either has a greater uptake of mercury than average or is unable to detoxify it. Many studies have tried to determine which of these mechanisms is to blame-I imagine it is a little of both. It has been proven that subjects with certain detox issues (they studied aluminum uptake in patients with Alzheimers and Down Syndrome) absorb many times more heavy metals than "normal" subjects. We already know that people with detox issues have trouble letting go of these things once they are in the body. It is thought that such people have ongoing deficiencies of certain minerals, and the body grabs on to whatever it thinks is close enough structurally to bind to the receptors.

The good news: experts are discovering that just replacing the mimic (heavy metal) with the required substance can help relieve the body burden of heavy metals. It is thought that a magnesium deficiency causes high aluminum (I can vouch ... More

What is mercury hypersensitivity? Well, officially, mercury hypersensitivity is a true allergic reaction to an amalgam filling, including redness, swelling, itching, and/or hives on the face/neck/torso. The term has come to mean something else in recent years--it refers to a person who either has a greater uptake of mercury than average or is unable to detoxify it. Many studies have tried to determine which of these mechanisms is to blame-I imagine it is a little of both. It has been proven that subjects with certain detox issues (they studied aluminum uptake in patients with Alzheimers and Down Syndrome) absorb many times more heavy metals than "normal" subjects. We already know that people with detox issues have trouble letting go of these things once they are in the body. It is thought that such people have ongoing deficiencies of certain minerals, and the body grabs on to whatever it thinks is close enough structurally to bind to the receptors.

The good news: experts are discovering that just replacing the mimic (heavy metal) with the required substance can help relieve the body burden of heavy metals. It is thought that a magnesium deficiency causes high aluminum (I can vouch for this one-I am chronically Mg deficient and had a terrible reaction to topical aluminum chloride given at the dentist), high cadmium may be related to low sodium, and methylmercury (for which PON1 mutants have a great affinity, according to various studies), when complexed with cysteine, is thought to be a mimic for methionine. A 2005 study (found here: http://www.ncbi.nlm.nih.gov/pubmed/16780353 ) indicated that the chemical structure of methylmercury + cysteine was not close enough to methionine to mimic exactly, but it was a less-specific amino acid mimicry that was likely to blame. In short, there is likely an amino acid deficiency at work.

While researchers have found that PON1 mutants have an incredible affinity for methylmercury, they also discovered that it complexed and was eliminated by...selenium. Selenium is also recommended in populations that eat a lot of high-mercury fish.
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I am PON 1 rs 2049649++ AA, rs662++ TT, rs854555++ CC, rs854561++ TT, & rs2299260+- CT., but I do not understand what is meant by "Hypersensitivity to Mercury". Is there an explanation somewhere? My MTHFR C677T is +- AG. My Quest Lab urine Mercury was <2mcg/L. Reference range was listed as <21mcg/L and Toxic as > or =150mgc/L. I believe you are correct, that urine alone is NOT an accurate method. In a Hair Mineral Test my Mercury was the only heavy metal that showed "out of the reference range" and up into the beginning of "Toxic Range". I had strong suspicions that I was Mercury Toxic even prior, and invested in doing Dr Chris Shade's Mercury Tri-Test that measures both Methyl Mercury from Fish and Inorganic Mercury from Dental Amalgams, via ratios of Hair to Urine and Blood to Urine. My total Mercury load was almost off the chart ! Here's a very recent Video with Dr Shade being interviewed by Dr Mercola: http://articles.mercola.com/sites/articles/archive/2016/06/19/heavy-metal-detoxification.aspx

I am also PON1++ and MTHFR C677T++, among other fun mutations (but MTHFR 1298 is normal). I have always been way more sensitive to environmental agents than anyone else I know (except my parents, who just don't admit they have terrible sensitivities). My mother is particularly sensitive to artificial sweeteners-they make her ill for days if she accidentally has a large dose (more than a sip of a diet beverage, etc). PON1 is implicated, based on study results, in sensitivity to mercury, pesticides, herbicides, insecticides (especially the professional mosquito treatments), and has been thought to play a causative role in Gulf War Syndrome.

On top of the fun environmental sensitivities, PON1 mutants have screwed up cholesterol levels (low HDL and high LDL). It was a relief to finally know why my cholesterol has been quite high since it was first measured (I was about 12. The doctors shrugged and assumed I needed a diet, as I was also obese.) PON1 mutants should also avoid fried foods due to the high levels of oxidated fats in used cooking oil (yes, there was a study where the participants drank a milkshake with used cooking oil in it...eww). In short, PON1 ... More

I am also PON1++ and MTHFR C677T++, among other fun mutations (but MTHFR 1298 is normal). I have always been way more sensitive to environmental agents than anyone else I know (except my parents, who just don't admit they have terrible sensitivities). My mother is particularly sensitive to artificial sweeteners-they make her ill for days if she accidentally has a large dose (more than a sip of a diet beverage, etc). PON1 is implicated, based on study results, in sensitivity to mercury, pesticides, herbicides, insecticides (especially the professional mosquito treatments), and has been thought to play a causative role in Gulf War Syndrome.

On top of the fun environmental sensitivities, PON1 mutants have screwed up cholesterol levels (low HDL and high LDL). It was a relief to finally know why my cholesterol has been quite high since it was first measured (I was about 12. The doctors shrugged and assumed I needed a diet, as I was also obese.) PON1 mutants should also avoid fried foods due to the high levels of oxidated fats in used cooking oil (yes, there was a study where the participants drank a milkshake with used cooking oil in it...eww). In short, PON1 is an antioxidant, so if you can't make much of it (like me), you have a lot of oxidative stress in your body. The good news: if your cholesterol levels are normal, you are probably not expressing this gene and don't need to worry about it.

The good news: PON1 appears to be induceable. I have been taking omega-3 fish oil (Vitamin Shoppe brand-highly rated and no fishy aftertaste, as far as I can tell) and drinking pomegranate juice every day and avoiding things that have been placed in a commercial deep fryer. I am not sure it's helping, but I do need all the help I can get.

In terms of metals, I have bad neurological reactions to aluminum (e.g., antiperspirants, topical preparations at the dentist, etc) and do have one remaining amalgam filling, but my understanding is that levels of heavy metals are best studied after a chelation regimen is started (to see how many metals your body is dumping).  Less

You said you are PON1 ++. Is that CC or TT? According to this:
https://livewello.com/health-reports/hypersensitivity-to-mercury it appears the at risk genotypes are MTHFR 1298 rs1801131 GT and PON1 rs662 AT